Extended Data Fig. 8: Enhanced retinoic acid signaling in pharyngeal arch 2 and AHF2 in response to hyperglycemia. | Nature Cardiovascular Research

Extended Data Fig. 8: Enhanced retinoic acid signaling in pharyngeal arch 2 and AHF2 in response to hyperglycemia.

From: Single-cell multimodal analyses reveal epigenomic and transcriptomic basis for birth defects in maternal diabetes

Extended Data Fig. 8: Enhanced retinoic acid signaling in pharyngeal arch 2 and AHF2 in response to hyperglycemia.

(A) Box plots of the distribution of ChromVAR deviation score for RAR and RXR transcription factor motifs for each cluster in the neural crest cell population. PA2 neural crest cells are highlighted in red. The X-axis shows the distribution of the Z-score. (STZ – red; VEH – blue) (n = 6 biological samples. n = 3 VEH replicates and n = 3 STZ replicates). (B) Box plots of the distribution of ChromVAR deviation score for RAR and RXR transcription factor motifs for each cluster in the mesoderm population. AHF2 cells are highlighted in red. The X-axis shows the distribution of the Z-score. (STZ – red; VEH – blue) (n = 6 biological samples. n = 3 VEH replicates and n = 3 STZ replicates). In the box plots, the central line indicates the median, box bounds represent the 25th and 75th percentiles, whiskers extend to values within 1.5 times the interquartile range, and outliers lie beyond this range.

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