Extended Data Fig. 1: Telemetry electrocardiogram (ECG) and cardiac magnetic resonance image (MRI) analysis in PKP2 Het mice. | Nature Cardiovascular Research

Extended Data Fig. 1: Telemetry electrocardiogram (ECG) and cardiac magnetic resonance image (MRI) analysis in PKP2 Het mice.

From: Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics

Extended Data Fig. 1

(a) Representative telemetry ECG tracings and premature ventricular contraction (PVC) counts from Ctrl and PKP2 heterozygous (Het) mice at 3 months of age. Red arrows indicate premature ventricular contractions. Scale bar = 0.1 s. Data are presented as mean ± S.E.M. n = 3 biologically independent animals examined per group, two-tailed unpaired t test, * p < 0.05 (p = 0.0135). (b) Quantification of end-diastolic volumes (EDV), end-systolic volumes (ESV) and percentage of ejection fraction (EF %) in WT and PKP2 Het mice at 10 months old of age using cardiac MRI. n = 4 biologically independent animals examined per group. Data are presented as mean ± S.E.M. Two-way ANOVA with Tukey’s multiple comparison test.

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