Fig. 6: Protective effect of rGAS6 administration against IR injury is dependent on ATF3. | Nature Cardiovascular Research

Fig. 6: Protective effect of rGAS6 administration against IR injury is dependent on ATF3.

From: ATF3 coordinates the survival and proliferation of cardiac macrophages and protects against ischemia–reperfusion injury

Fig. 6: Protective effect of rGAS6 administration against IR injury is dependent on ATF3.

a, Outline of rGAS6 (40 μg kg−1 d−1) or vehicle (IgG) treatment in WT or ATF3-CKO mice subjected to IR surgery. b–h. Plasma GAS6 levels (b), cardiac Atf3 mRNA expression (c), MerTK+ cardiac macrophages (d), EF (e), cardiac fibrosis (f) and CD31+ ECs (g and h) in WT or ATF3-CKO mice administered rGAS6 (g) or IgG (h) after IR (b, n = 8 mice per group; c–h, n = 6 mice per group). Statistical significance was evaluated using two-tailed, two-way ANOVA followed by Tukey’s multiple-comparison test (b–h). All data are presented as mean ± s.e.m.

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