Fig. 7: ATF3–GAS6 levels associated with the risk of MACEs in patients with ischemic heart disease. | Nature Cardiovascular Research

Fig. 7: ATF3–GAS6 levels associated with the risk of MACEs in patients with ischemic heart disease.

From: ATF3 coordinates the survival and proliferation of cardiac macrophages and protects against ischemia–reperfusion injury

Fig. 7: ATF3–GAS6 levels associated with the risk of MACEs in patients with ischemic heart disease.

a, Manhattan plot indicating GWASs highlighting SNPs in the 100-kb upstream and downstream of ATF3 correlated with the MACEs in patients with CAD. b, The eQTLs of ATF3 in the whole blood. c, Heatmap of pairwise linkage disequilibrium measurements for the 14 intersection SNPs. d, Plasma levels of GAS6 in patients with ischemia with poor or good CCC (n = 72 per group). e, Unadjusted and adjusted ORs obtained using a logical regression analysis for poor CCC. They were adjusted for drinking and CABG history. f, Pearson’s correlation between the plasma GAS6 and LVEF. g, Kaplan–Meier plots of major adverse events according to median values of plasma GAS6 levels at admission. Statistical significance was evaluated using two-tailed, unpaired Student’s t-tests (d), logistic regression analyses (a,e), Pearson’s correlations analysis (b,f) and log(rank) tests (g). OR, odds ratio.

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