Extended Data Fig. 4: Analysis of atherosclerosis in Ldlr−/−Trem2−/− mice.
From: TREM2 protects from atherosclerosis by limiting necrotic core formation
a-d) Analysis of atherosclerosis in Ldlr−/−Trem2−/− mice after 10 weeks with a) lesion coverage in the aorta (n = 6 male mice per genotype), b) plaque size in the aortic sinus (Ldlr−/−Trem2+/+: 11 males, 4 females; Ldlr−/−Trem2−/− n = 11 males, 5 females), c) macrophage coverage in aortic sinus lesions (expressed in percent of cellular plaque area; Ldlr−/−Trem2+/+: 12 males, 5 females; Ldlr−/−Trem2−/− n = 12 males, 6 females) and d) necrotic core relative size (expressed in percent of total plaque area; Ldlr−/−Trem2+/+: 12 males, 5 females; Ldlr−/−Trem2−/− n = 12 males, 6 females) in aortic sinus lesions; e-g) analysis of atherosclerosis in Ldlr−/−Trem2−/− mice after 20 weeks of HFD feeding with e) plaque size in the aortic sinus (Ldlr−/−Trem2+/+: 9 males, 6 females; Ldlr−/−Trem2−/− n = 9 males, 6 females), f) macrophage coverage in aortic sinus lesions (Ldlr−/−Trem2+/+: 9 males, 7 females; Ldlr−/−Trem2−/− n = 11 males, 6 females) and g) necrotic core relative size in aortic sinus lesions (Ldlr−/−Trem2+/+: 9 males, 7 females; Ldlr−/−Trem2−/− n = 11 males, 6 females). Open circles: female mice; filled circles: male mice. Data presented as mean +/− SEM together with individual data point distribution. Statistical test: two-tailed Mann Whitney test (all panels).
