Fig. 1: Study design.

The comorbidity between MDD and CVD was investigated using genetic and causal inference methods, including assessing overlap with and mediation through shared risk factors (blood pressure, psychosocial or lifestyle, childhood maltreatment, metabolic and inflammation; Supplementary Table 1). The risk factor group psychosocial or lifestyle is abbreviated to psychosocial. Created with BioRender.com (license agreements VG26BG3VTL, MK26BG46H3).