Extended Data Fig. 8: Genetic correlation between MDD and CVD adjusting for individual risk factors. | Nature Cardiovascular Research

Extended Data Fig. 8: Genetic correlation between MDD and CVD adjusting for individual risk factors.

From: Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Extended Data Fig. 8: Genetic correlation between MDD and CVD adjusting for individual risk factors.

Results from Genomic SEM. Points and error bars represent mean genetic correlation and 95% confidence intervals. Reference estimates of the association without any adjustment are printed in black. Sample sizes for underlying GWAS summary statistics are reported in Supplementary Table 1. AF=Atrial Fibrillation; CAD=Coronary Artery Disease; Child. Mal.=Childhood Maltreatment; CRP=C-Reactive Protein; DBP=Diastolic Blood Pressure; Edu=Educational attainment; HDL=High-Density Lipoprotein; HF=Heart Failure; IL6=Interleukin-6; LDL=Low-Density Lipoprotein; MDD=Major Depressive Disorder; NonHDL=Non-High-Density Lipoprotein; PAD=Peripheral Artery Disease; Phys. Act.=Physical activity; PP=Pulse Pressure; Psychosocial=Psychosocial/lifestyle; SBP=Systolic Blood Pressure; T2D=Type II Diabetes; TC=Total Cholesterol; TG=Triglycerides.

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