Extended Data Fig. 7: Expression of angiogenic factors in BMPER iECKO mice with BMP9/10 Abs treatment.
From: A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling
BMPER iECKO and control mice at 12 weeks were subjected to HLI surgery and injected with BMP9/10 bAbs or IgG (2.5 mg/kg). At day 2 after Abs injection, gastrocnemius muscle in the calf from ligated side was collected and RNA was extracted for Q-PCR. (a) Expression of Vegfa, Vegfc, Pdgfa, Pdgfb, Angpt1 and Angpt2 in BMPER iECKO mice with BMP9/10 bAbs or IgG treatment after HLI surgery, normalized to control mice with IgG, n = 5 mice per group. Data are presented as means ± s.e.m. Statistics calculated by one-way ANOVA with Tukey’s multiple comparison tests. ns, not significant.
