Fig. 1: Numbers of proteins associated with the three CVD outcomes and gene expression level look-up. | Nature Cardiovascular Research

Fig. 1: Numbers of proteins associated with the three CVD outcomes and gene expression level look-up.

From: Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank

Fig. 1

a, A Venn diagram visualizing the overlap of measured protein levels associated with incident CVDs by Cox proportional hazards regression after Bonferroni correction (P < 0.000017, two sided). Only the numbers of proteins are given. For details, see Supplementary Tables 6–8. b, A Venn diagram visualizing the overlap of genetically predicted levels of proteins associated with the three CVDs (CHD, IS and HF) on MR analysis (Wald ratio method). Only proteins with an FDR <0.05 (two sided) are shown. c, The expression levels of genes coding proteins found to be significant by MR analysis were looked up in human heart and artery tissues on the GTEx Portal. TPM, transcripts per million.

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