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Cardiomyocyte maturation and metabolism

tRNA methylation drives early postnatal cardiomyocyte maturation

Nature Cardiovascular Research volume 3, pages 1375–1376 (2024)Cite this article

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The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.

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Fig. 1: Methylation of tRNA by METTL1 in cardiomyocytes during early postnatal life drives functional maturation.

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Acknowledgements

This work was funded in part by the California Institute for Regenerative Medicine (TRAN1-12907) to P.R.L. and by the US National Institutes of Health (R01 HL130840 and P01 HL141084) to M.M.

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Authors and Affiliations

  1. Regencor, Inc., San Carlos, CA, USA

    Pilar Ruiz-Lozano

  2. National Heart Lung Institute, Imperial College London, London, UK

    Pilar Ruiz-Lozano

  3. Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA

    Mark Mercola

  4. Department of Medicine, Stanford University, Stanford, CA, USA

    Mark Mercola

  5. Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA

    Mark Mercola

Authors
  1. Pilar Ruiz-Lozano
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  2. Mark Mercola
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Correspondence to Mark Mercola.

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Ruiz-Lozano, P., Mercola, M. tRNA methylation drives early postnatal cardiomyocyte maturation. Nat Cardiovasc Res 3, 1375–1376 (2024). https://doi.org/10.1038/s44161-024-00572-3

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