Extended Data Fig. 5: Representative histologic staining with HE and EVG showing focal dissection in the aortas of three SMC-Notch1−/− mice at the age of 40 weeks, and lethal dissection in the aortas of SMC-Mfn1/2−/− mice.
From: Correcting mitochondrial loss mitigates NOTCH1-related aortopathy in mice
The focal dissections were histologically characterized by a loss of continuity in at least three adjacent inner elastic laminae of the tunica media. Black arrows depict focal dissections. The dissections in SMC-Notch1−/− mice were primarily located in regions close to the heart (root to the ascending aorta). The dissections in SMC-Mfn1/2−/− mice could be found in different regions of aortas in different mice. All mice were male and subjected to tamoxifen injection.
