Extended Data Fig. 4: SMC-selective Trpm7 deficiency improves ascending aortopathies.
From: The TRPM7 chanzyme in smooth muscle cells drives abdominal aortic aneurysm in mice
(a) Echocardiographic images, H&E staining, EVG staining, in situ gelatin zymography of the ascending aorta (AscAo). n = 5. Scale bar=1 mm for Echo. 100μm for staining and 400μm for low-power H&E field. (b) Internal diameter determined with echocardiography at longitudinal image scans. n = 7-13. (c) Medial thickness analyzed from EVG staining. The region between internal and external elastic lamina defines tunica media. n = 5. (d) Elastin breakdowns analyzed from EVG staining. n = 6. (e) Analysis of MMP activity determined with in situ gelatin zymography. n = 3. The differences were analyzed using two-way ANOVA, followed by Tukey’s post-hoc test (Extended Data Figs. 4b–e).
