Extended Data Fig. 7: Increased inflammation levels and ARID5A expression in aged human hearts.

a, The circular heatmap showing the expression fold change (aged vs. young) of top 50 age-related down-regulated DEGs with the highest frequency of occurrence across multiple cell types. The intensity of color reflects the level of expression in aged cells for each gene. b, Network visualizing the up- and down-regulated aging-related DEGs across all cell types, which overlapped with genes annotated in the Aging Atlas database. Node size represents the frequency at which DEGs appear across various cell types, while red and blue parts of the nodes represent up- and downregulated genes, respectively. c, The dendrogram depicts the hierarchical clustering of gene co-expression modules based on topological overlap matrix (TOM) in single-nucleus transcriptome sequencing data of human cardiac tissue. d, The violin plots showing the AUC scores of hub genes from module 2 for each cell type in human cardiac tissue across young and aged groups. The dots within the violin plots represent the median, while the whiskers indicate a range of 1.5 times the interquartile distance. e, The bar plot showing the enriched GO terms or pathways for hub genes from module 2.