Extended Data Fig. 6: ANGPT1 expression in human and mouse tissues.
From: Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations
(a) Organ-wide average gene expression (normalized transcripts per million, nTPM), of ANGPT1 in different cell types, extracted from Human Protein Atlas scRNA-seq data. ANGPT1 expression in SMCs is highlighted in red and in BECs in blue. (b) Gene expression of ANGPT1 and selected mural cell markers in different skin cell types extracted from Human Protein Atlas scRNA-seq data. (c) Whole mount immunofluorescence of ANGPT1+ SMCs (αSMA) associated with veins (arrows) but not arteries (arrowhead) in the ear skin of a control mouse. Similar results were obtained from 3 mice in 2 independent experiments. Scale bars: 50 μm.
