Extended Data Fig. 5: Differentiation trajectory terminating on cardiac progenitor cells. | Nature Cardiovascular Research

Extended Data Fig. 5: Differentiation trajectory terminating on cardiac progenitor cells.

From: Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment

Extended Data Fig. 5: Differentiation trajectory terminating on cardiac progenitor cells.

a, Gene expression and ATAC gene score dynamics of ETV2 in Dox+ and Dox– EC trajectories across pseudotime. b, UMAP visualization of the cardiac progenitor trajectory of Dox– cells. Each cell is colored by its pseudotime and each cluster is annotated by sample collection time. The smoothed arrow represents a visualization of the interpreted trajectory in the UMAP embedding. c, Gene expression and ATAC gene score dynamics of the CDH5, ETV2, and cardiac progentior genes MEF2C and HAND2. d, Heatmap of TF regulators for which ATAC gene score is positively correlated with chromVAR TF deviation (motif deviation) across the Dox– cardiac progenitor trajectory, ordered by pseudotime.

Back to article page