Extended Data Fig. 6: Genetically downregulated IL-6 signaling via perturbation in IL6 is associated with lower risk of atherosclerotic cardiovascular disease in Biobank Japan.
From: IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk
Data are presented as odds ratios per 24% decrease in CRP; error bars correspond to 95% confidence intervals. Results from two-sample Mendelian randomization analyses (inverse variance weighted method) using variant weights and association estimates from Biobank Japan. The exact p-values and FDR-adjusted p-values are presented in Supplementary Table 12. All reported p-values are two-sided. Abbreviations: IL-6, interleukin-6; CRP, C-reactive protein; CI, confidence interval; OR, odds ratio.
