Fig. 4: Genetically downregulated IL-6 signaling via perturbation in IL6 is associated with lower risk of ASCVD.
From: IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk
The results from two-sample MR analyses (IVW method) scaled to a 24% decrease in CRP levels. The datasets used for each outcome are detailed in Supplementary Table 1. Data are presented as ORs per 24% decrease in CRP and error bars correspond to 95% CI. Asterisks indicate significant heterogeneity (Cochran’s Q test, P < 0.05) between the effects of IL6 and IL6R instruments. The exact P values and FDR-adjusted P values (Benjamini–Hochberg method) are presented in Supplementary Table 9. All reported P values are two sided.
