Extended Data Fig. 2: Associations of genetically proxied IL-6 signaling activity through (a) 12, (b) 8, and (c) 3 IL6 genetic variants, as captured by decreases in serum log-transformed CRP (x-axis) with circulating IL-6 levels (scaled in SD units, y-axis) in inverse-variance weighted and Egger Mendelian randomization analysis.
From: IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk
Each point represents an effect estimate for a genetic variant, with horizontal and vertical error bars indicating the 95% confidence intervals (CI) for CRP and IL-6 reductions, respectively. CRP associations derived from UK Biobank (n = 464,264 individuals); IL-6 associations derived from Konieczny et al. (Commun Biol 8, 34, 2025; n = 74,679 individuals). All reported p-values are two-sided. Abbreviations: CRP, C-reactive protein; IL-6, interleukin-6; CI, confidence interval; OR, odds ratio; SD, standard deviation; IVW, inverse-variance weighted; MR, Mendelian randomization.
