Fig. 1: SMCs in atherosclerosis express immunogenic RNA and show evidence of ISG induction in phenotypic modulation. | Nature Cardiovascular Research

Fig. 1: SMCs in atherosclerosis express immunogenic RNA and show evidence of ISG induction in phenotypic modulation.

From: Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis

Fig. 1

a, Schematic of ADAR1 RNA editing of dsRNA. b, UMAP of scRNA-seq data from human carotid atherosclerotic plaques (Alsaigh et al.24); Endo, endothelial cells; Fibro, fibroblasts; NKT, natural killer T cells; CTL, cytotoxic T lymphocytes; DC, dendritic cells; Mac, macrophages. c, Module score of immunogenic RNA expression. d–f, Clustering of SMC subset (d) with a violin plot showing the SMC marker MYH11 (e) and FMC/CMC marker TNFRSF11B (f). g–i, Violin plots of the expression of ISGs ISG15 (g), IF135 (h) and IFI16 (i). j, Dot plot of the top ISGs within SMC clusters. k–n, Using a mouse comprehensive integrated dataset of lineage-traced SMCs (from Sharma et al.32), feature plots were generated of Myh11 (k) and Col2a1 (l) at 0 and 16 weeks of a high-fat diet and of Isg15 (l) and Ifit3 (m) in SMC phenotypic modulation.

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