Extended Data Fig. 8: SMC specific haploinsufficiency in Adar1 increased SMC lineage traced cell content in plaque without change in acellular area. | Nature Cardiovascular Research

Extended Data Fig. 8: SMC specific haploinsufficiency in Adar1 increased SMC lineage traced cell content in plaque without change in acellular area.

From: Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis

Extended Data Fig. 8

Representative images of tdTomato (SMC derived) and overlay images with FITC and brightfield images in control (Adar1WT/WT, Myh11CreERT2, ROSAtdTomato, ApoE−/−) (a) and SMC Adar1 het (Adar1fl/WT, Myh11CreERT2, ROSAtdTomato, ApoE−/−)(b) genotypes. Quantification of the percentage of tdTomato positive area in the plaque (c) and in the top 30 μm segment of the plaque representing the cap (d). Masson’s Trichrome staining with threshold analysis and acellular area quantification in control (e) and SMC-Adar1−/+ mice (f) with quantification (g). N = 13 per group. P-values represent t-test for comparison.

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