Extended Data Fig. 7: laminar profile of mvPI and RI in ACA, MCA, and PCA.
From: Assessing cerebral microvascular volumetric with high-resolution 4D cerebral blood volume MRI at 7 T
Laminar profiles of mvPI (left) and RI (right) in ACA (a), MCA (b), and PCA (c). The blue and red curves represent the results for younger and elder participants, respectively. The light blue shaded area indicates the white matter area, and the light green shaded area indicates the CSF area. WMd and WMs in x axis represent the deep white matter and superficial white matter. The values on the x-axis from 1 to 0 represent the gray matter from deep to superficial. The blue and red statistical values represent the differences between young and old participants compared to chance levels, while the black values indicate the direct differences between young and old participants. Statistical significance for all panels was assessed using a two-sided bootstrap test (10,000 resamples). Bonferroni factor = 9. Young n = 11 and older n = 11 independent biological replicates, representing individual human participants, each measured once. Exact p values are shown in the figure. Error bars indicate SEM across participants. *: corrected p < 0.05; **: corrected p < 0.01; ***: corrected p < 0.001. The exact corrected p-values for the comparison between young and older from deep WM to pia are: 0.195, 0.003, 0.344, 0.371, 0.046, 0.312, 0.935, 9*0.162, 9*0.252 in ACA; <0.001, 0.005, 0.072, 0.136, 0.045, 0.012, 0.015, 0.011, 0.028 in MCA; 9*0.220, 0.057, 0.023, 0.024, 0.034, 0.014, 0.028, 0.083, 0.381 in PCA.
