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Epidemiology

Sex differences in the association of physical activity with coronary heart disease incidence and mortality

Physical activity lowers the risk of cardiovascular disease and overall mortality. Research now shows that women may derive greater cardiovascular benefit from exercise than men.

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Fig. 1: Sex differences in the association of moderate-to-vigorous physical activity with incident coronary heart disease.

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Acknowledgements

E.S.L. is supported by the NIH (K23-HL159243, R01HL180648), the American Heart Association, the Massachusetts Life Sciences Center, and the Tianqiao and Chrissy Chen Institute.

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Correspondence to Emily S. Lau.

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E.S.L. consults or serves on advisory boards for SystoleHealth, Inc, Amissa Health and Roon, unrelated to this work.

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Lau, E.S. Sex differences in the association of physical activity with coronary heart disease incidence and mortality. Nat Cardiovasc Res 4, 1457–1458 (2025). https://doi.org/10.1038/s44161-025-00734-x

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