This study examines electrical conduction through fibrotic regions in a mouse model of arrhythmogenic cardiomyopathy. A correlative imaging approach that integrates macroscopic cardiac electrophysiology with microscale whole-heart morphological reconstructions showed that the effect of fibrosis on conduction depends on the pacing frequency.
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This is a summary of: Giardini, F. et al. Correlative imaging integrates electrophysiology with three-dimensional murine heart reconstruction to reveal electrical coupling between cell types. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-025-00728-9 (2025).
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Myocardial fibrosis promotes arrhythmias at fast pacing rates. Nat Cardiovasc Res 4, 1462–1463 (2025). https://doi.org/10.1038/s44161-025-00738-7
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DOI: https://doi.org/10.1038/s44161-025-00738-7
