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Reversible gene therapy for cardiac repair and protection

Nature Cardiovascular Research volume 4, pages 1596–1597 (2025)Cite this article

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We developed an adeno-associated virus-based, conditional and reversible gene therapy. Using this approach to transiently induce YAP activation in cardiomyocytes either before or after ischemic injury in mice, we could improve cardiac function.

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Fig. 1: CM-YAPon protects the mouse heart against myocardial infarction.

References

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This is a summary of: Meng, F. et al. Gene therapy CM-YAPon protects the mouse heart from myocardial infarction. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-025-00744-9 (2025).

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Reversible gene therapy for cardiac repair and protection. Nat Cardiovasc Res 4, 1596–1597 (2025). https://doi.org/10.1038/s44161-025-00747-6

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