Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Myocardial infarction

Lipomatous metaplasia after myocardial infarction is a consequence of fibroblast-specific TGFβ signaling loss

Nature Cardiovascular Research volume 4, page 1448 (2025)Cite this article

Subjects

Myocardial infarction occurs when arterial blood flow to the heart muscle is restricted or cut off, causing ischemic damage. People who survive myocardial infarction develop cardiac scars with adipose tissue infiltration which may contribute to dysfunction and arrhythmogenesis. Although observed for decades, the cellular origin of this lipomatous metaplasia has remained enigmatic.

In a study recently published in Circulation, Tuleta et al. delineated a novel molecular mechanism mediating fibroblast-to-adipocyte conversion in infarcted hearts, causing the fatty infiltration after myocardial infarction.

This is a preview of subscription content, access via your institution

Access options

Author information

Authors and Affiliations

  1. BMC Cardiovascular Disorders https://bmccardiovascdisord.biomedcentral.com/

    Xiulin Koehler

Authors
  1. Xiulin Koehler
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Xiulin Koehler.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Koehler, X. Lipomatous metaplasia after myocardial infarction is a consequence of fibroblast-specific TGFβ signaling loss. Nat Cardiovasc Res 4, 1448 (2025). https://doi.org/10.1038/s44161-025-00753-8

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s44161-025-00753-8

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing