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Modeling HFpEF in animals

Nature Cardiovascular Research volume 4, pages 1589–1591 (2025)Cite this article

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There is great interest in modeling human HFpEF in animals to identify underlying mechanisms and ultimately improve sorely needed therapies. Our current models are a step forward but still fall short in several crucial ways, particularly by not capturing the severity of heart failure features common in patients.

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Fig. 1: HFpEF animal models.

References

  1. Hamo, C. E. et al. Nat. Rev. Dis. Primers 10, 55 (2024).

    Article  PubMed  Google Scholar 

  2. Borlaug, B. A. et al. Cardiovasc. Res. 118, 3434–3450 (2023).

    Article  PubMed  Google Scholar 

  3. Schiattarella, G. G. et al. Nature 568, 351–356 (2019).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Adrah, Y. et al. Cardiovasc. Res. https://doi.org/10.1093/cvr/cvaf174 (2025).

  5. Schauer, A. et al. ESC Heart Fail. 7, 2123–2134 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Kass, D. A. J. Mol. Cell Cardiol. 197, 1–4 (2024).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Chen, Y. et al. Hypertension 59, 1170–1178 (2012).

    Article  PubMed  CAS  Google Scholar 

  8. Bozkurt, B. et al. J. Card. Fail. 31, 66–116 (2025).

    Article  PubMed  Google Scholar 

  9. Tong, D. et al. Circulation 140, 1769–1771 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hahn, V. S. et al. Circulation 143, 120–134 (2021).

    Article  PubMed  CAS  Google Scholar 

  11. Jani, V. P. et al. J. Am. Heart Ass. 14, e038945 (2025).

    Article  CAS  Google Scholar 

  12. Hahn, V. S. et al. Circulation 147, 1147–1161 (2023).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Koleini, N. et al. Eur. J. Heart Fail. 26, 1941–1951 (2024).

    PubMed  CAS  Google Scholar 

  14. Aslam, M. I. et al. Circulation 143, 965–967 (2021).

    Article  PubMed  Google Scholar 

  15. Packer, M. J. Am. Coll. Cardiol. 86, 1269–1373 (2025).

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This work was supported by NIH R35-HL166565.

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  1. Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    David A. Kass

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  1. David A. Kass
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Correspondence to David A. Kass.

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The author declares no competing interests related to this work.

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Kass, D.A. Modeling HFpEF in animals. Nat Cardiovasc Res 4, 1589–1591 (2025). https://doi.org/10.1038/s44161-025-00754-7

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