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Vascular disease

Linking thromboembolism to the pathogenesis of long COVID

Nature Cardiovascular Research volume 4, pages 1594–1595 (2025)Cite this article

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Long COVID is a major global health challenge but the underlying mechanisms are unclear, hampering the development of effective therapies. Evidence points to a causal link between thromboembolic processes and symptom persistence, suggesting a role for vascular and coagulation abnormalities in the pathogenesis of this complex syndrome.

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Fig. 1: Venous thromboembolism risk is associated with the development of long COVID.

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Acknowledgements

The authors thank A. Ajanel for help with the figure, and acknowledge funding support from the National Institutes of Health (NIH; R01HL163019 and R01HL160808, to R.A.C.) and the American Heart Association (24SCEFIA1262494, to F.D.).

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Authors and Affiliations

  1. Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

    Frederik Denorme & Robert A. Campbell

  2. Laboratory of Cell Biology and Histology, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium

    Frederik Denorme

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  1. Frederik Denorme
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  2. Robert A. Campbell
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Correspondence to Robert A. Campbell.

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Denorme, F., Campbell, R.A. Linking thromboembolism to the pathogenesis of long COVID. Nat Cardiovasc Res 4, 1594–1595 (2025). https://doi.org/10.1038/s44161-025-00756-5

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