Fig. 1: Overview of the HLS tissue dissociation strategy.

a Schematic of the Hypersonic Levitation and Spinning (HLS) principle. b Structure of the triple-acoustic resonator probe and the hydrodynamic force it generates via hypersonic streaming. c Illustration of the automated tissue dissociation apparatus integrating dissociation and filtration functions. d Dissociation outcomes showing improved rare cell preservation, enhanced cell activity, and increased cell yield achieved by the HLS method.