Table 2 Heart-rate variability-derived measures of the four ANS clusters

From: Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank

 

MP-Cluster N = 3731

HRS-Cluster N = 5158

LRS-Cluster N = 5339

HP-Cluster N = 1540

overall P-value

pairwise

BPM (M ± SD)

56.5 ± 8.3

64.0 ± 9.9

63.8 ± 9.5

59.2 ± 12.0

<0.001

HRS,LRS > HP > MP

SDNN (M ± SD)

45.8 ± 17.4

26.0 ± 12.3

20.4 ± 10.1

74.0 ± 18.7

<0.001

HP > MP > HRS > LRS

RMSSD (M ± SD)

45.0 ± 20.5

18.1 ± 9.8

19.4 ± 10.9

76.5 ± 29.9

<0.001

HP > MP > LRS > HRS

pNN20 (M ± SD)

0.6 ± 0.1

0.2 ± 0.2

0.3 ± 0.2

0.7 ± 0.2

<0.001

HP > MP > LRS > HRS

pNN50 (M ± SD)

0.2 ± 0.1

0.02 ± 0.03

0.02 ± 0.04

0.3 ± 0.2

<0.001

HP > MP > HRS, LRS

MAD (M ± SD)

27.6 ± 10.1

16.2 ± 7.4

12.6 ± 5.2

39.4 ± 15.4

<0.001

HP > MP > HRS > LRS

SD1 (M ± SD)

31.4 ± 14.1

12.7 ± 6.9

13.6 ± 7.6

53.5 ± 20.9

<0.001

HP > MP > LRS > HRS

SD2 (M ± SD)

52.7 ± 20.3

33.1 ± 15.2

24.0 ± 11.7

81.3 ± 21.1

<0.001

HP > MP > HRS > LRS

BR (M ± SD)

0.20 ± 0.06

0.15 ± 0.04

0.23 ± 0.05

0.19 ± 0.06

<0.001

LRS > MP > HP > HRS

LF (M ± SD)

459.8 ± 445.1

274.4 ± 309.4

72.2 ± 95.0

1425.0 ± 964.6

<0.001

HP > MP > HRS > LRS

HF (M ± SD)

449.9 ± 340.7

77.7 ± 97.2

127.2 ± 143.9

1592.8 ± 1042.7

<0.001

HP > MP > LRS > HRS

TP (M ± SD)

896.6 ± 565.1

358.4 ± 374.1

200.2 ± 208.2

3204.4 ± 1239.9

<0.001

HP > MP > HRS > LRS

LFnu (M ± SD)

45.0 ± 25.7

74.0 ± 15.7

35.5 ± 20.2

49.0 ± 28.3

<0.001

HRS > HP > MP > LRS

Female sex – N (col%)

2,179 (58.4%)

2,088 (40.5%)

3,303 (61.9%)

812 (52.7%)

<0.001

LRS > MP > HP > HRS

Age (M ± SD)

61.8 ± 8.0

65.2 ± 7.5

65.4 ± 7.6

63.6 ± 8.4

<0.001

HRS, LRS > HP > MP

BMI (M ± SD)

25.9 ± 4.1

26.6 ± 4.0

26.8 ± 4.5

26.4 ± 4.1

<0.001

LRS > HRS, HP > MP

  1. MP Medium Parasympathetic, HRS High relative Sympathetic, LRS Low relative Sympathetic, HP High Parasympathetic, M Mean, SD Standard Deviation, Col % Column Percent, BPM beats per minute, SDNN Standard deviation for intervals between adjacent beats, RMSSD Root mean square of successive differences between adjacent R-R intervals, pNN20/pNN50 Proportion of differences greater than 20 ms or 50 ms, MAD Median absolute deviation heart rate, SD1/SD2 Standard deviation in the two orthogonal directions of the Poincaré plot (for frequency domain), BR Breathing rate, LF Low frequency component power, HF High frequency component power, LFnu Normalized low frequency power, TP Total heart rate variability power, BMI Body Mass Index.
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