Multiple sclerosis is a neurological disease that involves white matter lesions throughout the brain, and depression is a common comorbidity. In this paper, Siddiqi, Kletenik et al. propose the use of a recently developed technique known as lesion network mapping to identify a common depression network that may represent a treatment target for neuromodulatory approaches to treating depression.
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References
Bolwig, T. G. & Fink, M. J. ECT 25, 15–18 (2009).
Arêas, F. Z. et al. Arq. Neuropsiquiatr. 78, 733–735 (2020).
Schoonheim, M. M. et al. Neuroimage Clin. 35 (2022).
Siddiqi, S. H. & Kletenik, I. et al. Nat. Mental Health https://doi.org/10.1038/s44220-022-00002-y (2022).
Tomasi, D. & Volkow, N. D. Cereb. Cortex 21, 2003–2013 (2011).
Boes, A. D. Brain 144, 5 (2021).
Padmanabhan, J. L. et al. Biol. Psychiatry 86, 749–758 (2019).
Siddiqi, S. H. et al. Nat. Hum. Behav. 5, 1707–1716 (2021).
Etkin, A. Biol. Psychiatry 86, 732–733 (2019).
Fernando, C. et al. Front. Comput. Neurosci. 6, 24 (2012).
Haier, R. J. et al. Intelligence 16, 415–426 (1992).
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Leavitt, V.M. Conceptualizing the brain as a collection of circuits of dysfunction. Nat. Mental Health 1, 8–9 (2023). https://doi.org/10.1038/s44220-022-00004-w
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DOI: https://doi.org/10.1038/s44220-022-00004-w
