Research articles

This meta-analysis by Luo et al. shows high rates of mental disorders among homeless children and youth—especially substance use and conduct disorders—revealing major global data gaps and an urgent need for targeted mental health support.

This single-group meta-analysis of randomized controlled trials examined clozapine monotherapy efficacy across the schizophrenia spectrum in both treatment-resistant and non-treatment-resistant populations. The study revealed higher clozapine response rates than previously reported, underscoring the importance of a timely initiation of clozapine therapy.

This scoping review highlights the potential of mobile and wearable technologies for continuous monitoring of depressive symptoms. Analyzing 52 studies, it identifies key predictive features and demonstrates that personalized models substantially enhance accuracy in just-in-time depression prediction.

In this population-based cohort study, John et al. evaluated the long-term impact of childhood ADHD traits on adult psychological distress and identified societal exclusion as an indirect pathway linking early ADHD traits to poorer midlife mental health.

This research evaluated a single-blinded clinical trial comparing ketamine-assisted psychotherapy combined with Mindfulness-Oriented Recovery Enhancement (MORE) against MORE alone for opioid use disorder, demonstrating significant reductions in drug use and cravings without any serious adverse events.

This study investigated the computational mechanisms linking momentary craving and decision-making in people with moderate to high addiction risk levels for alcohol or cannabis use, uncovering different mechanisms of alcohol and cannabis addiction risk and implying the need for substance-specific interventions.

In this study, the authors examine the potential shared genetic vulnerability across externalizing traits related to substance use and to substance use disorders.

In this systematic review and meta-analysis, the authors investigate how cardiorespiratory fitness relates to the risk of developing mental and neurocognitive disorders

In this study, Agathos et al. examine alterations in thalamocortical network connectivity during cognitive restructuring of negative cognitions in individuals with post-traumatic stress disorder, using ultrahigh-field 7-T functional MRI and dynamic causal modeling.

Using retrospective health-record analyses, Hidalgo-Padilla et al. evaluated whether differences in remote versus in-person primary care consultations were associated with subsequent use of acute mental health services in the UK.

A triple meta-analysis evaluates the effectiveness of transcranial electrical stimulation for obsessive–compulsive disorder treatment through three meta-analytic methods, revealing a moderate therapeutic effect and identifying specific interventions that enhance therapeutic outcomes, guiding future treatment optimization strategies.

In this study, long-term effects of PM_2.5-bound copper and zinc on depression in older US adults are investigated, finding significant associations with increased depression rates, emphasizing the need for public health interventions targeting environmental contaminants affecting mental health.

In this study, Constable et al. examine the association between exposure to sexual and physical violence and enduring transdiagnostic psychopathological traits in a diverse sample of 842 adults.

This analysis conducted an umbrella review of 36 systematic reviews assessing psychological capacity trajectories. The findings indicate prevalent low-symptom patterns, highlighting gender and socioeconomic factors as risks, while emphasizing the need for diverse, quality assessments in future studies.

Using plasma proteome profiles from over 53,000 UK Biobank participants, Zhang et al. examined proteins associated with suicidal behavior and investigated pathways that could explain the association

Wang et al. analyzed data from the Detroit Neighborhood Health Study to explore links between social adversity, post-traumatic stress and epigenetic regulation through blood-derived micro-RNA profiles.

This study investigates whether genetic predisposition to systemic inflammation affects cortical thinning trajectories and the risk for psychopathology in adolescents, using data from the Adolescent Brain Cognitive Development Study.

This research identifies two neural factors linked to externalizing and internalizing symptoms through a longitudinal imaging-genetic cohort. Distinct neural configurations and cognitive-behavioral relevance highlight the need for tailored therapeutic strategies addressing psychiatric comorbidity across developmental stages.

In this study, the authors perform a comprehensive series of analyses to assess the role of disruptions in brain state dynamics in major depressive disorder, using data from the UK Biobank.