Fig. 3: MR plots for the relationship between lifestyle and depression.

a, Scatter plot of SNP effects on lifestyle versus depression, with the slope of each line corresponding to the estimated MR effect per method. The data are expressed as raw β values with 95% CI values. b, Model-based sensitivity analyses from four methods (n = 26 SNPs). The effect estimates represent the odds ratio for depression per one-point increment in healthy lifestyle score. Data are presented as mean values ± s.e.m. The width of the lines extending from the center point represent the 95% CI. Two-sided unadjusted association P values from four models are given.