Fig. 4: Association of mental state attributions between drug condition.
a, In both real and simulated data (n = 28), haloperidol (red) versus placebo (blue) induced a trial-wise negative Pearson association (±s.e.m.) between harmful intent and self-interest, which decayed over time for both real (R = 0.52, P = 0.029) and simulated (R = 0.65, P = 0.0046) data. The right-most panel shows the marginal effect (box plots demonstrate minimum, interquartile range, median and maximum values) of trial-wise correlations between conditions. Using linear regression, we show that the difference between Pearson correlations between haloperidol and placebo was significant for both real (estimate = 2.26, SE = 0.33, P = 9.29 × 10−8) and simulated (estimate = 2.23, SE = 0.44, P = 1.84 × 10−5) data. *** = P < 0.001. b, There was a general negative Pearson association (±s.e.m.) between harmful intent and self-interest found under haloperidol for mean attributions across all 18 trials; this was not true for the placebo. c, Summary of main effects between drug conditions on self and other oriented intentional attributions following social outcomes. Both trial-wise and averaged associative analyses indicate that other-oriented attributions concerning self-interest of others (black), and self-oriented attributions concerning the harmful intent of others (red), are independent under the placebo (PLAC) but coupled under haloperidol (HALO). Under haloperidol this coupling is biased towards exaggeration of other-oriented attributions and diminishment of self-oriented attributions.
