Fig. 2: Amygdala iERP response to sad and happy faces.
From: Brain mechanisms underlying the emotion processing bias in treatment-resistant depression
a, Amygdala iERPs from 5 patients with TRD (20 contacts in left amygdala and 16 contacts in right amygdala) and 12 control patients (34 contacts in left amygdala and 18 contacts in right amygdala) to sad and happy faces were averaged across contacts. The shaded area indicates s.e.m. b, Time windows of early-stage (black horizontal bars) and late-stage (grey horizontal bars) amygdala iERP response. The red dot depicts the time point of the average peak amplitude. c, Peak amplitude differences in bilateral amygdala between the TRD and control groups within the early stage and the late stage for each condition (sad and happy faces). The centre line indicates the median, and the bottom and top edge of the box indicates the 25th and 75th percentiles, respectively. The whiskers indicate 1.5 × the interquartile range up to the minimum and maximum, and the points indicate outliers. The peak amplitude of the early stage was significantly larger in the TRD group compared with the control group during sad-face processing (t86 = 2.695, P = 0.009). The peak amplitude of the late stage was significantly smaller in patients with TRD compared with the control group in the happy-face condition (t84 = 3.610, P = 0.001). *P < 0.05 (two-sided unpaired t-tests).
