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Determining pathways that link brain, body, lifestyle and mental health

Nature Mental Health volume 2, pages 1140–1141 (2024)Cite this article

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Using multimodal brain imaging and organ-specific physiological markers from more than 18,000 adult participants of the UK Biobank database, this study reveals integrated pathways that explain the interplay between brain, body, environment and lifestyle, and their collective influence on mental health outcomes.

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Fig. 1: Pathways linking brain, body, lifestyle and depression.

References

  1. Kessler, R. C. et al. Anxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Surveys. Epidemiol. Psychiatr. Sci. 24, 210–226 (2015). This paper reports the comorbidity rates of depression and anxiety disorders.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gold, S. M. et al. Comorbid depression in medical diseases. Nat. Rev. Dis. Primers 6, 69 (2020). This review outlines the comorbidity rates of depression in chronic medical diseases.

    Article  PubMed  Google Scholar 

  3. Roy-Byrne, P. P. et al. Anxiety disorders and comorbid medical illness. Gen. Hosp. Psychiatry 30, 208–225 (2008). This review discusses the comorbidity rates of anxiety in chronic medical diseases.

    Article  PubMed  Google Scholar 

  4. Winter, N. R. et al. Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities. JAMA Psychiatry 79, 879–888 (2022). This paper reports alterations in brain structure and function in major depressive disorder.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tian, Y. E. et al. Evaluation of brain-body health in individuals with common neuropsychiatric disorders. JAMA Psychiatry 80, 567–576 (2023). This paper reports poor brain and body health in four common neuropsychiatric disorders.

    Article  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Tian, Y. E. et al. Brain, lifestyle and environmental pathways linking physical and mental health. Nat. Mental Health https://doi.org/10.1038/s44220-024-00303-4 (2024).

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Determining pathways that link brain, body, lifestyle and mental health. Nat. Mental Health 2, 1140–1141 (2024). https://doi.org/10.1038/s44220-024-00307-0

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