Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$79.00 per year
only $6.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Schumann, G. et al. Nat. Mental Health https://doi.org/10.1038/s44220-024-00314-1 (2024).
Nesse, R. M. World Psychiatry 22, 177–202 (2023).
Lonsdale, J. et al. Nat. Genet. 45, 580–585 (2013).
Bird, A. Nature 447, 396–398 (2007).
Cecil, C. A. M. et al. J. Psychiatr. Res. 83, 184–194 (2016).
Alameda, L. et al. Psychol. Med. 52, 1645–1665 (2022).
Edgar, R. D., Jones, M. J., Meaney, M. J., Turecki, G. & Kobor, M. S. Transl. Psychiatry 7, e1187 (2017).
Jia, T. et al. Mol. Psychiatry 26, 3884–3895 (2021).
Atianand, M. K. & Fitzgerald, K. A. Trends Mol. Med. 20, 623–631 (2014).
Cui, M., Cheng, C. & Zhang, L. Lab. Invest. 102, 1170–1181 (2022).
Blume, J. E. et al. Nat. Commun. 11, 3662 (2020).
Mascarell Maričić, L. et al. Mol. Psychiatry 25, 2648–2671 (2020).
Wekesa, J. S. & Kimwele, M. Front. Genet. https://doi.org/10.3389/fgene.2023.1199087 (2023).
Acknowledgements
This work was supported by the Horizon 2021 (grant 101057429) and UK Research and Innovation (grants 10038599 and 10041392)-funded project environMENTAL. Other funding included the Medical Research Council and Medical Research Foundation (MR/R00465X/, MRF-058-0004-RG-DESRI, ‘ESTRA’- Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents; and MR/S020306/1, MRF-058-0009-RG-DESR-C0759 ‘ESTRA’-Establishing causal relationships between biopsychosocial predictors and correlates of eating disorders and their mediation by neural pathways), the EU-funded FP6 Integrated Project IMAGEN (reinforcement-related behavior in normal brain function and psychopathology; LSHM-CT- 2007-037286), the Horizon 2020-funded European Research Council advanced grant for STRATIFY (brain network-based stratification of reinforcement-related disorders; 695313) and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. This paper represents independent research, partly funded by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The authors thank C. Schmäl for proofreading the manuscript.
Author information
Authors and Affiliations
Consortia
Corresponding author
Ethics declarations
Competing interests
M.M.N. and P.H. have received fees for membership in the advisory board from HMG Systems Engineering GmbH. M.M.N. has received fees for membership in the Medical-Scientific Editorial Office of the Deutsches Ärzteblatt, for review activities from the European Research Council, and for serving as a consultant for EVERIS Belgique SPRL in a project of the European Commission (REFORM/SC2020/029). M.M.N., P.H. and S.H.H. receive salary payments from Life & Brain GmbH. M.M.N. holds shares in Life & Brain GmbH.
Rights and permissions
About this article
Cite this article
Desrivières, S., Miller, A., Mathey, C.M. et al. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. Nat. Mental Health 2, 1131–1133 (2024). https://doi.org/10.1038/s44220-024-00317-y
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s44220-024-00317-y
