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Digital cognitive twins in mental health

Nature Mental Health volume 3, pages 1106–1108 (2025)Cite this article

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Digital cognitive twins could transform cognitive training into a personalized, clinically grounded and ethically governed modality for preventive use.

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Fig. 1: Illustration of a new framework offering a compelling new standard for preventive care for brain health.

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Acknowledgements

P.M.D. and D.P.D. are supported by US National Institute on Aging grant 2R01AG052440.

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Authors and Affiliations

  1. Neurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine and Duke Institute for Brain Sciences, Durham, NC, USA

    P. Murali Doraiswamy

  2. Centro de Investigación Nebrija en Cognición (CINC), Nebrija University, Madrid, Spain

    Jon Andoni Duñabeitia

  3. CogniFit, San Francisco, CA, USA

    Carlos Rodriguez

  4. Division of Geriatric Psychiatry, New York State Psychiatric Institute and Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA

    Davangere P. Devanand

Authors
  1. P. Murali Doraiswamy
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  2. Jon Andoni Duñabeitia
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  3. Carlos Rodriguez
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  4. Davangere P. Devanand
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Corresponding author

Correspondence to Jon Andoni Duñabeitia.

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Competing interests

P.M.D. and D.P.D. are supported by US National Institute on Aging grant 2R01AG052440, for which CogniFit provides the training platform, but have no other financial relationships with CogniFit. P.M.D. has received research grants, advisory fees and/or stock from several companies in this field for other projects, and serves on the boards of Apollo Hospitals Enterprise Limited (AHEL) and the Live Love Laugh Foundation. D.P.D. is a scientific consultant to Acadia, Eisai and GSK. J.A.D. serves as a scientific advisor for CogniFit.

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Nature Mental Health thanks Tadao Ooka for their contribution to the peer review of this work.

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Doraiswamy, P.M., Duñabeitia, J.A., Rodriguez, C. et al. Digital cognitive twins in mental health. Nat. Mental Health 3, 1106–1108 (2025). https://doi.org/10.1038/s44220-025-00482-8

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