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Regional adiposity shapes neural system vulnerability in brain and cognitive aging

Nature Mental Health volume 3, pages 1114–1115 (2025)Cite this article

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Our analyses of multimodal data from brain magnetic resonance imaging and body dual-energy X-ray absorptiometry in adults reveal that fat accumulation in specific body regions contributes to differential neural vulnerabilities and cognitive aging, independently of body mass index.

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Fig. 1: System-specific brain age gaps mediate adiposity–cognition associations.

References

  1. Blüher, M. Obesity: global epidemiology and pathogenesis. Nat. Rev. Endocrinol. 15, 288–298 (2019). This paper reports a comprehensive overview of the worldwide prevalence of obesity and its underlying biological mechanisms.

    Article  PubMed  Google Scholar 

  2. Bischof, G. N. & Park, D. C. Obesity and aging: consequences for cognition, brain structure, and brain function. Psychosom. Med. 77, 697–709 (2015). This review summarizes the relationships among obesity, cognitive decline, and structural and functional abnormalities in the brain.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Santos, A. L. & Sinha, S. Obesity and aging: molecular mechanisms and therapeutic approaches. Ageing Res. Rev. 67, 101268 (2021). This review presents the mechanisms and complexity underlying the relationship between obesity and aging.

    Article  PubMed  Google Scholar 

  4. Fantuzzi, G. Adipose tissue, adipokines, and inflammation. J. Allergy. Clin. Immunol. 115, 911–920 (2005). This review presents how visceral adipose tissue promotes the release of pro-inflammatory factors.

    Article  PubMed  Google Scholar 

  5. Alser, M. & Elrayess, M. A. From an apple to a pear: moving fat around for reversing insulin resistance. Int. J. Environ. Res. Public Health 19, 14251 (2022). This review presents the potential protective effects of lower-body adipose tissue.

    Article  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Zhang, D. et al. Regional adiposity shapes brain and cognition in adults. Nat. Ment. Health https://doi.org/10.1038/s44220-025-00501-8 (2025).

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Regional adiposity shapes neural system vulnerability in brain and cognitive aging. Nat. Mental Health 3, 1114–1115 (2025). https://doi.org/10.1038/s44220-025-00513-4

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