Fig. 2: PGS-CRP is associated with variations in age-related cortical thinning during adolescence, with the strongest acceleration effect in the medial temporal lobe.
This figure illustrates the interaction between PGS-CRP and age. The top row shows the standardized regression coefficients (β3) for the interaction term (age × PGS-CRP), with darker blue indicating stronger associations with accelerated cortical thinning. The middle row highlights regions where the interaction term was significant at meta-analysis P < 0.05), and the bottom row identifies regions that survive FDR correction in the meta-analysis (PFDR < 0.05). Statistical analysis used two-sided LME models with individual, family and site as random intercepts. Effects reflect standardized regression coefficients (beta/β) from ancestry-stratified analyses, combined using inverse-weighted meta-analysis. Multiple comparisons across regions were controlled using Benjamini–Hochberg FDR. Exact P values and 95% confidence intervals are provided in Supplementary Table 1.
