Fig. 4: Regional association between PGS-CRP effects on cortical thinning and neurotransmitter receptor gradients.
a, The left panel shows the regional age × PGS-CRP interaction effects (standardized β coefficients) mapped onto the cortical surface. The right panel shows neurotransmitter receptor distributions based on PET receptor binding for corresponding regions. These neurotransmitter maps illustrate spatial receptor gradients; the colors are not indicative of specific data values or quantitative comparisons. b, The scatterplot depicts Pearson’s correlation coefficients (r) between the regional PGS-CRP cortical-thinning effects and PET-derived neurotransmitter receptor gradients. X-axis labels correspond to serotonin receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT4 and 5-HT6) and the serotonin transporter (5-HTT); the cannabinoid type-1 receptor (CB1); dopamine receptors (D1 and D2) and dopamine transporter (DAT); gamma-aminobutyric acid type-A receptor (GABAA_AA R); histamine H3 receptor (H3); muscarinic acetylcholine receptor M1 (M1) and vesicular acetylcholine transporter (VAChT); the norepinephrine transporter (NET); the metabotropic glutamate receptor 5 (mGluR5); and the mu-opioid receptor (MOR). Red points indicate significant correlations (Puncorrected < 0.05). Statistical analysis used two-sided Pearson correlations, and spatial autocorrelation-preserving null models were used to generate significance thresholds. Exact correlation coefficients, P values and FDR-corrected values are provided in Supplementary Table 5.
