Table 1 Brain regions with significant PGS-CRP by age interaction effects on cortical thinning

Regions	Data source¹	β²	SE³	P	P_FDR
Right entorhinal cortex⁴	Meta analysis	−0.016	0.005	0.002	0.049
Right entorhinal cortex	EU sample	−0.019	0.007	0.008	0.493
Right entorhinal cortex	Non-EU sample	−0.014	0.008	0.098	0.308
Right insula cortex	Meta analysis	−0.018	0.005	0.001	0.049
Right insula cortex	EU sample	−0.016	0.007	0.028	0.493
Right insula cortex	Non-EU sample	−0.021	0.008	0.010	0.104
Right superior temporal gyrus	Meta analysis	−0.013	0.004	0.002	0.049
Right superior temporal gyrus	EU sample	−0.012	0.005	0.024	0.493
Right superior temporal gyrus	Non-EU sample	−0.015	0.007	0.026	0.139

¹Participants were stratified by genetic ancestry into two groups to address population stratification: individuals of European ancestry (EU sample) and non-European ancestry (non-EU sample). LME models were performed separately in each group, and a meta-analysis was conducted to integrate findings across both groups. Statistical significance was determined through meta-analysis, with a threshold of P < 0.05 after FDR correction.
²β, beta coefficient of PGS-CRP by age interaction effect on cortical thickness.
³SE, standard error.
⁴Bolded rows indicate statistically significant results (P_FDR < 0.05).

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