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Fractal-inspired ultrapermeable membranes for electricity-free portable nanofiltration

Abstract

Nanofiltration is an effective technology for producing clean water through the removal of harmful pathogens, micropollutants and ions. However, its dependence on a power supply and complex configuration hinder the deployment of nanofiltration systems in underserved regions. To support universal access to clean water in these regions, we have developed an ultrapermeable polyamide nanofiltration membrane that can be used in an electricity-free portable purifier. The membrane features a nature-inspired substrate that mimics the highly efficient fractal transport structures found in leaves and blood vessels. The polyamide nanofilm supported by this unique fractal substrate achieved a record-high permeance of 113.6 l m−2 h−1 bar−1, an order of magnitude higher than current commercial benchmarks. The design enabled rapid water purification by simple manual vacuum pumping, producing over 250 ml of pure water within 15 min using small palm-sized membrane disks with an area of 157 cm2. Furthermore, the nanofiltration membrane exhibited 98.0% Na2SO4 rejection, along with exceptional removal of pathogens (>99.9999%) and micropollutants (for example, 99.1% of perfluorooctanesulfonate). By delivering high-quality purified water without the need for any electricity, this portable purifier offers a practical solution that is aligned with the United Nations Sustainable Development Goal 6, focusing on clean water and sanitation.

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Fig. 1: Fractal-like substrates for enhancing the water permeance of PA nanofiltration membranes.
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Fig. 2: Properties of fractal-like substrates.
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Fig. 3: Morphology and separation performance of nanofiltration membranes.
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Fig. 4: Water purification performance of uPA nanofiltration membranes.
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Fig. 5: Prototype of an electricity-free portable nanofiltration purifier and its purification performance.
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All of the data generated in this study are available within the Article and its Supplementary Information. Source data are provided with this paper.

References

  1. Liu W. et al. Pressure-driven membrane desalination. Nat. Rev. Methods Primers 4, 10 (2024).

  2. Shao, S. et al. Nanofiltration membranes with crumpled polyamide films: a critical review on mechanisms, performances, and environmental applications. Environ. Sci. Technol. 56, 12811–12827 (2022).

    CAS  PubMed  Google Scholar 

  3. Wang, R., He, R., He, T., Elimelech, M. & Lin, S. Performance metrics for nanofiltration-based selective separation for resource extraction and recovery. Nat. Water 1, 291–300 (2023).

    Google Scholar 

  4. Freger, V. & Ramon, G. Z. Polyamide desalination membranes: formation, structure, and properties. Prog. Polym. Sci. 122, 101451 (2021).

    CAS  Google Scholar 

  5. Sarkar, P., Wu, C., Yang, Z. & Tang, C. Y. Empowering ultrathin polyamide membranes at the water–energy nexus: strategies, limitations, and future perspectives. Chem. Soc. Rev. 53, 4374–4399 (2024).

    CAS  PubMed  Google Scholar 

  6. Zhang, S. et al. Ultrathin membranes for separations: a new era driven by advanced nanotechnology. Adv. Mater. 34, 2108457 (2022).

    CAS  Google Scholar 

  7. Sarkar, P. et al. Fast water transport through sub-5 nm polyamide nanofilms: the new upper-bound of the permeance–selectivity trade-off in nanofiltration. J. Mater. Chem. A 9, 20714–20724 (2021).

    CAS  Google Scholar 

  8. Wang, F., Yang, Z. & Tang, C. Y. Modeling water transport in interlayered thin-film nanocomposite membranes: gutter effect vs funnel effect. ACS EST Eng. 2, 2023–2033 (2022).

    CAS  Google Scholar 

  9. Zhou, H., Qiu, Z., Zeng, J., Dai, R. & Wang, Z. Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. J. Membr. Sci. 688, 122125 (2023).

    CAS  Google Scholar 

  10. Park, H. B., Kamcev, J., Robeson, L. M., Elimelech, M. & Freeman, B. D. Maximizing the right stuff: the trade-off between membrane permeability and selectivity. Science 356, eaab0530 (2017).

    PubMed  Google Scholar 

  11. Yang, Z. et al. A critical review on thin-film nanocomposite membranes with interlayered structure: mechanisms, recent developments, and environmental applications. Environ. Sci. Technol. 54, 15563–15583 (2020).

    CAS  PubMed  Google Scholar 

  12. Long L. et al. Assessment of permeance and selectivity of thin-film composite polyamide membranes for diverse applications. Nat. Water 3, 668–682 (2025).

  13. Hu, Y., Wang, F., Yang, Z. & Tang, C. Y. Modeling nanovoid-enhanced water permeance of thin film composite membranes. J. Membr. Sci. 675, 121555 (2023).

    CAS  Google Scholar 

  14. Hu, Y. et al. Design ultrathin polyamide membranes against funnel effect: a novel zone-of-influence-based approach. Environ. Sci. Technol. 59, 10600–10607 (2025).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Jayalalitha, G., Shanthoshini Deviha, V. & Uthayakumar, R. Fractal model for blood flow in cardiovascular system. Comput. Biol. Med. 38, 684–693 (2008).

    CAS  PubMed  Google Scholar 

  16. Lu, Y. et al. Two-dimensional fractal nanocrystals templating for substantial performance enhancement of polyamide nanofiltration membrane. Proc. Natl Acad. Sci. USA 118, e2019891118 (2021).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Wang, Z. et al. Highly efficient droplet generation device based on a three-dimensional fractal structure. Chem. Eng. Sci. 282, 119227 (2023).

    CAS  Google Scholar 

  18. Wang, L. et al. Computer simulation of the packing of nanoparticles. Powder Technol. 401, 117317 (2022).

    CAS  Google Scholar 

  19. Wolf, D. E. & Pöschel T. in Packing Problems in Soft Matter Physics: Fundamentals and Applications (eds Chan, H.-K. et al.) Vol. 27, 517–541 (Royal Society of Chemistry, 2025).

  20. Nasiri, N., Elmøe, T. D., Liu, Y., Qin, Q. H. & Tricoli, A. Self-assembly dynamics and accumulation mechanisms of ultra-fine nanoparticles. Nanoscale 7, 9859–9867 (2015).

    CAS  PubMed  Google Scholar 

  21. Singh, S. C. et al. Solar-trackable super-wicking black metal panel for photothermal water sanitation. Nat. Sustain. 3, 938–946 (2020).

    Google Scholar 

  22. Yang, J. et al. A bioinspired capillary force-induced driving strategy for constructing ultra-low-pressure separation membranes. Adv. Funct. Mater. 33, 2214661 (2023).

    CAS  Google Scholar 

  23. The water crisis is worsening. Researchers must tackle it together. Nature 613, 611–612 (2023).

  24. Jiang, M. et al. A bio-based nanofibre hydrogel filter for sustainable water purification. Nat. Sustain. 7, 168–178 (2024).

    Google Scholar 

  25. Wang, H.-L., Cui, J.-Y. & Jiang, W.-F. Synthesis, characterization and flocculation activity of novel Fe(OH)3–polyacrylamide hybrid polymer. Mater. Chem. Phys. 130, 993–999 (2011).

    CAS  Google Scholar 

  26. Song, Y. et al. Alkaline hydrolysis and flocculation properties of acrylamide-modified cellulose polyelectrolytes. Carbohydr. Polym. 86, 171–176 (2011).

    CAS  Google Scholar 

  27. Feng, Q. et al. Adsorption and desorption characteristics of arsenic on soils: kinetics, equilibrium, and effect of Fe(OH)3 colloid, H2SiO3 colloid and phosphate. Procedia Environ. Sci. 18, 26–36 (2013).

    CAS  Google Scholar 

  28. Lo, B. & Waite, T. D. Structure of hydrous ferric oxide aggregates. J. Colloid Interface Sci. 222, 83–89 (2000).

    CAS  PubMed  Google Scholar 

  29. Gilbert, B., Lu, G. & Kim, C. S. Stable cluster formation in aqueous suspensions of iron oxyhydroxide nanoparticles. J. Colloid Interface Sci. 313, 152–159 (2007).

    CAS  PubMed  Google Scholar 

  30. Dale, J. G., Stegemeier, J. P. & Kim, C. S. Aggregation of nanoscale iron oxyhydroxides and corresponding effects on metal uptake, retention, and speciation: I. ionic-strength and pH. Geochim. Cosmochim. Acta 148, 100–112 (2015).

    CAS  Google Scholar 

  31. Fauzi, U., Hoerdt, A. & Neubauer, F. M. Influence of coordination number and percolation probability on rock permeability estimation. Geophys. Res. Lett. 29, 78-1–78-4 (2002).

    Google Scholar 

  32. Wu, C., Long, L., Yang, Z. & Tang, C. Y. Porous substrate affects fouling propensity of thin-film composite nanofiltration membranes. J. Membr. Sci. Lett. 2, 100036 (2022).

    Google Scholar 

  33. Hunt, A., Ewing, R. & Ghanbarian B. Percolation Theory for Flow in Porous Media (Springer, 2014).

  34. Zhang, X. & Lorente, S. The growth of capillary networks by branching for maximum fluid access. Sci. Rep. 13, 11278 (2023).

    PubMed  PubMed Central  Google Scholar 

  35. Long, L. et al. NaHCO3 addition enhances water permeance and Ca/haloacetic acids selectivity of nanofiltration membranes for drinking water treatment. Water Res. 242, 120255 (2023).

    CAS  PubMed  Google Scholar 

  36. Peng, L. E. et al. Tailoring polyamide rejection layer with aqueous carbonate chemistry for enhanced membrane separation: mechanistic insights, chemistry-structure-property relationship, and environmental implications. Environ. Sci. Technol. 53, 9764–9770 (2019).

    CAS  PubMed  Google Scholar 

  37. Jiang, K. et al. Precise regulation of monomer reactive sites enhances the water permeance and membrane selectivity of polyamide nanofiltration membranes. Ind. Eng. Chem. Res. 62, 19813–19821 (2023).

    CAS  Google Scholar 

  38. Xue, Y.-R. et al. Harmonic amide bond density as a game-changer for deciphering the crosslinking puzzle of polyamide. Nat. Commun. 15, 1539 (2024).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Zhao, Y. et al. Extra-thin composite nanofiltration membranes tuned by γ-cyclodextrins containing amphipathic cavities for efficient separation of magnesium/lithium ions. Sep. Purif. Technol. 286, 120419 (2022).

    CAS  Google Scholar 

  40. Gan, B. et al. Ultra-permeable silk-based polymeric membranes for vacuum-driven nanofiltration. Nat. Commun. 15, 8656 (2024).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Furcas, F. E., Mundra, S., Lothenbach, B. & Angst, U. M. Speciation controls the kinetics of iron hydroxide precipitation and transformation at alkaline pH. Environ. Sci. Technol. 58, 19851–19860 (2024).

    PubMed  PubMed Central  Google Scholar 

  42. Le Berre, J. F., Gauvin, R. & Demopoulos, G. P. A study of the crystallization kinetics of scorodite via the transformation of poorly crystalline ferric arsenate in weakly acidic solution. Colloids Surf. A 315, 117–129 (2008).

    Google Scholar 

  43. Calcium and Magnesium in Drinking-Water: Public Health Significance (World Health Organization, 2009).

  44. Yang, Z., Long, L., Wu, C. & Tang, C. Y. High permeance or high selectivity? Optimization of system-scale nanofiltration performance constrained by the upper bound. ACS EST Eng. (2021).

  45. Pulizzi, F. & Sun, W. Treating water with nano. Nat. Nanotechnol. 13, 633 (2018).

    CAS  PubMed  Google Scholar 

  46. Hannah, D. M. et al. Water and sanitation for all in a pandemic. Nat. Sustain. 3, 773–775 (2020).

    Google Scholar 

  47. Comprehensive Disinfectants and Disinfection Byproducts Rules (Stage 1 and Stage 2): Quick Reference Guide 1–5 (US EPA, 2010).

  48. Maqbool, T. et al. Exploring the relative changes in dissolved organic matter for assessing the water quality of full-scale drinking water treatment plants using a fluorescence ratio approach. Water Res. 183, 116125 (2020).

    CAS  PubMed  Google Scholar 

  49. Li, L. et al. New advances in fluorescence excitation-emission matrix spectroscopy for the characterization of dissolved organic matter in drinking water treatment: a review. Chem. Eng. J. 381, 122676 (2020).

    CAS  Google Scholar 

  50. Guidelines for Drinking-Water Quality: Small Water Supplies 149–151 (WHO, 2024).

  51. Guo, H. et al. Nanofiltration for drinking water treatment: a review. Front. Chem. Sci. Eng. 16, 681–698 (2022).

    CAS  PubMed  Google Scholar 

  52. Huang, J. et al. Polymeric membranes with highly homogenized nanopores for ultrafast water purification. Nat. Sustain. 7, 901–909 (2024).

    Google Scholar 

  53. Guo, H. et al. High-efficiency capture and recovery of anionic perfluoroalkyl substances from water using PVA/PDDA nanofibrous membranes with near-zero energy consumption. Environ. Sci. Technol. Lett. 8, 350–355 (2021).

    CAS  Google Scholar 

  54. Ma, D. et al. Absolute and fast removal of viruses and bacteria from water by spraying-assembled carbon-nanotube membranes. Environ. Sci. Technol. 55, 15206–15214 (2021).

    CAS  PubMed  Google Scholar 

  55. Baer, A. & Kehn-Hall, K. Viral concentration determination through plaque assays: using traditional and novel overlay systems. J. Vis. Exp. 93, e52065 (2014).

    Google Scholar 

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Acknowledgements

The work was substantially supported by the Research Grants Council of the Hong Kong Special Administration Region, China (SRFS2021-7S04, C.Y.T.).

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Contributions

B.G., L.E.P. and C.Y.T. conceived the idea and designed the research. B.G., W.L., Z.W. and Y.H. performed the experiments. Z.Y., Q.G., P.-F.S. and Q.X. provided constructive suggestions for the results. B.G., L.E.P. and C.Y.T. contributed to the writing of the manuscript.

Corresponding authors

Correspondence to Lu Elfa Peng or Chuyang Y. Tang.

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Nature Water thanks Xiao-mao Wang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Supplementary Information (download PDF )

Supplementary Discussion, Methods, Figs. 1–29, Videos 1 and 2, and Table 1.

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Supplementary Video 1 (download MP4 )

The filtration process of the Fr-uPA purifier.

Supplementary Video 2 (download MP4 )

Video showing that the manual pump is easy to operate by hand.

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Gan, B., Hu, Y., Liu, W. et al. Fractal-inspired ultrapermeable membranes for electricity-free portable nanofiltration. Nat Water 4, 68–77 (2026). https://doi.org/10.1038/s44221-025-00551-3

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