Abstract
Nanofiltration is an effective technology for producing clean water through the removal of harmful pathogens, micropollutants and ions. However, its dependence on a power supply and complex configuration hinder the deployment of nanofiltration systems in underserved regions. To support universal access to clean water in these regions, we have developed an ultrapermeable polyamide nanofiltration membrane that can be used in an electricity-free portable purifier. The membrane features a nature-inspired substrate that mimics the highly efficient fractal transport structures found in leaves and blood vessels. The polyamide nanofilm supported by this unique fractal substrate achieved a record-high permeance of 113.6 l m−2 h−1 bar−1, an order of magnitude higher than current commercial benchmarks. The design enabled rapid water purification by simple manual vacuum pumping, producing over 250 ml of pure water within 15 min using small palm-sized membrane disks with an area of 157 cm2. Furthermore, the nanofiltration membrane exhibited 98.0% Na2SO4 rejection, along with exceptional removal of pathogens (>99.9999%) and micropollutants (for example, 99.1% of perfluorooctanesulfonate). By delivering high-quality purified water without the need for any electricity, this portable purifier offers a practical solution that is aligned with the United Nations Sustainable Development Goal 6, focusing on clean water and sanitation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout





Similar content being viewed by others
Data availability
All of the data generated in this study are available within the Article and its Supplementary Information. Source data are provided with this paper.
References
Liu W. et al. Pressure-driven membrane desalination. Nat. Rev. Methods Primers 4, 10 (2024).
Shao, S. et al. Nanofiltration membranes with crumpled polyamide films: a critical review on mechanisms, performances, and environmental applications. Environ. Sci. Technol. 56, 12811–12827 (2022).
Wang, R., He, R., He, T., Elimelech, M. & Lin, S. Performance metrics for nanofiltration-based selective separation for resource extraction and recovery. Nat. Water 1, 291–300 (2023).
Freger, V. & Ramon, G. Z. Polyamide desalination membranes: formation, structure, and properties. Prog. Polym. Sci. 122, 101451 (2021).
Sarkar, P., Wu, C., Yang, Z. & Tang, C. Y. Empowering ultrathin polyamide membranes at the water–energy nexus: strategies, limitations, and future perspectives. Chem. Soc. Rev. 53, 4374–4399 (2024).
Zhang, S. et al. Ultrathin membranes for separations: a new era driven by advanced nanotechnology. Adv. Mater. 34, 2108457 (2022).
Sarkar, P. et al. Fast water transport through sub-5 nm polyamide nanofilms: the new upper-bound of the permeance–selectivity trade-off in nanofiltration. J. Mater. Chem. A 9, 20714–20724 (2021).
Wang, F., Yang, Z. & Tang, C. Y. Modeling water transport in interlayered thin-film nanocomposite membranes: gutter effect vs funnel effect. ACS EST Eng. 2, 2023–2033 (2022).
Zhou, H., Qiu, Z., Zeng, J., Dai, R. & Wang, Z. Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. J. Membr. Sci. 688, 122125 (2023).
Park, H. B., Kamcev, J., Robeson, L. M., Elimelech, M. & Freeman, B. D. Maximizing the right stuff: the trade-off between membrane permeability and selectivity. Science 356, eaab0530 (2017).
Yang, Z. et al. A critical review on thin-film nanocomposite membranes with interlayered structure: mechanisms, recent developments, and environmental applications. Environ. Sci. Technol. 54, 15563–15583 (2020).
Long L. et al. Assessment of permeance and selectivity of thin-film composite polyamide membranes for diverse applications. Nat. Water 3, 668–682 (2025).
Hu, Y., Wang, F., Yang, Z. & Tang, C. Y. Modeling nanovoid-enhanced water permeance of thin film composite membranes. J. Membr. Sci. 675, 121555 (2023).
Hu, Y. et al. Design ultrathin polyamide membranes against funnel effect: a novel zone-of-influence-based approach. Environ. Sci. Technol. 59, 10600–10607 (2025).
Jayalalitha, G., Shanthoshini Deviha, V. & Uthayakumar, R. Fractal model for blood flow in cardiovascular system. Comput. Biol. Med. 38, 684–693 (2008).
Lu, Y. et al. Two-dimensional fractal nanocrystals templating for substantial performance enhancement of polyamide nanofiltration membrane. Proc. Natl Acad. Sci. USA 118, e2019891118 (2021).
Wang, Z. et al. Highly efficient droplet generation device based on a three-dimensional fractal structure. Chem. Eng. Sci. 282, 119227 (2023).
Wang, L. et al. Computer simulation of the packing of nanoparticles. Powder Technol. 401, 117317 (2022).
Wolf, D. E. & Pöschel T. in Packing Problems in Soft Matter Physics: Fundamentals and Applications (eds Chan, H.-K. et al.) Vol. 27, 517–541 (Royal Society of Chemistry, 2025).
Nasiri, N., Elmøe, T. D., Liu, Y., Qin, Q. H. & Tricoli, A. Self-assembly dynamics and accumulation mechanisms of ultra-fine nanoparticles. Nanoscale 7, 9859–9867 (2015).
Singh, S. C. et al. Solar-trackable super-wicking black metal panel for photothermal water sanitation. Nat. Sustain. 3, 938–946 (2020).
Yang, J. et al. A bioinspired capillary force-induced driving strategy for constructing ultra-low-pressure separation membranes. Adv. Funct. Mater. 33, 2214661 (2023).
The water crisis is worsening. Researchers must tackle it together. Nature 613, 611–612 (2023).
Jiang, M. et al. A bio-based nanofibre hydrogel filter for sustainable water purification. Nat. Sustain. 7, 168–178 (2024).
Wang, H.-L., Cui, J.-Y. & Jiang, W.-F. Synthesis, characterization and flocculation activity of novel Fe(OH)3–polyacrylamide hybrid polymer. Mater. Chem. Phys. 130, 993–999 (2011).
Song, Y. et al. Alkaline hydrolysis and flocculation properties of acrylamide-modified cellulose polyelectrolytes. Carbohydr. Polym. 86, 171–176 (2011).
Feng, Q. et al. Adsorption and desorption characteristics of arsenic on soils: kinetics, equilibrium, and effect of Fe(OH)3 colloid, H2SiO3 colloid and phosphate. Procedia Environ. Sci. 18, 26–36 (2013).
Lo, B. & Waite, T. D. Structure of hydrous ferric oxide aggregates. J. Colloid Interface Sci. 222, 83–89 (2000).
Gilbert, B., Lu, G. & Kim, C. S. Stable cluster formation in aqueous suspensions of iron oxyhydroxide nanoparticles. J. Colloid Interface Sci. 313, 152–159 (2007).
Dale, J. G., Stegemeier, J. P. & Kim, C. S. Aggregation of nanoscale iron oxyhydroxides and corresponding effects on metal uptake, retention, and speciation: I. ionic-strength and pH. Geochim. Cosmochim. Acta 148, 100–112 (2015).
Fauzi, U., Hoerdt, A. & Neubauer, F. M. Influence of coordination number and percolation probability on rock permeability estimation. Geophys. Res. Lett. 29, 78-1–78-4 (2002).
Wu, C., Long, L., Yang, Z. & Tang, C. Y. Porous substrate affects fouling propensity of thin-film composite nanofiltration membranes. J. Membr. Sci. Lett. 2, 100036 (2022).
Hunt, A., Ewing, R. & Ghanbarian B. Percolation Theory for Flow in Porous Media (Springer, 2014).
Zhang, X. & Lorente, S. The growth of capillary networks by branching for maximum fluid access. Sci. Rep. 13, 11278 (2023).
Long, L. et al. NaHCO3 addition enhances water permeance and Ca/haloacetic acids selectivity of nanofiltration membranes for drinking water treatment. Water Res. 242, 120255 (2023).
Peng, L. E. et al. Tailoring polyamide rejection layer with aqueous carbonate chemistry for enhanced membrane separation: mechanistic insights, chemistry-structure-property relationship, and environmental implications. Environ. Sci. Technol. 53, 9764–9770 (2019).
Jiang, K. et al. Precise regulation of monomer reactive sites enhances the water permeance and membrane selectivity of polyamide nanofiltration membranes. Ind. Eng. Chem. Res. 62, 19813–19821 (2023).
Xue, Y.-R. et al. Harmonic amide bond density as a game-changer for deciphering the crosslinking puzzle of polyamide. Nat. Commun. 15, 1539 (2024).
Zhao, Y. et al. Extra-thin composite nanofiltration membranes tuned by γ-cyclodextrins containing amphipathic cavities for efficient separation of magnesium/lithium ions. Sep. Purif. Technol. 286, 120419 (2022).
Gan, B. et al. Ultra-permeable silk-based polymeric membranes for vacuum-driven nanofiltration. Nat. Commun. 15, 8656 (2024).
Furcas, F. E., Mundra, S., Lothenbach, B. & Angst, U. M. Speciation controls the kinetics of iron hydroxide precipitation and transformation at alkaline pH. Environ. Sci. Technol. 58, 19851–19860 (2024).
Le Berre, J. F., Gauvin, R. & Demopoulos, G. P. A study of the crystallization kinetics of scorodite via the transformation of poorly crystalline ferric arsenate in weakly acidic solution. Colloids Surf. A 315, 117–129 (2008).
Calcium and Magnesium in Drinking-Water: Public Health Significance (World Health Organization, 2009).
Yang, Z., Long, L., Wu, C. & Tang, C. Y. High permeance or high selectivity? Optimization of system-scale nanofiltration performance constrained by the upper bound. ACS EST Eng. (2021).
Pulizzi, F. & Sun, W. Treating water with nano. Nat. Nanotechnol. 13, 633 (2018).
Hannah, D. M. et al. Water and sanitation for all in a pandemic. Nat. Sustain. 3, 773–775 (2020).
Comprehensive Disinfectants and Disinfection Byproducts Rules (Stage 1 and Stage 2): Quick Reference Guide 1–5 (US EPA, 2010).
Maqbool, T. et al. Exploring the relative changes in dissolved organic matter for assessing the water quality of full-scale drinking water treatment plants using a fluorescence ratio approach. Water Res. 183, 116125 (2020).
Li, L. et al. New advances in fluorescence excitation-emission matrix spectroscopy for the characterization of dissolved organic matter in drinking water treatment: a review. Chem. Eng. J. 381, 122676 (2020).
Guidelines for Drinking-Water Quality: Small Water Supplies 149–151 (WHO, 2024).
Guo, H. et al. Nanofiltration for drinking water treatment: a review. Front. Chem. Sci. Eng. 16, 681–698 (2022).
Huang, J. et al. Polymeric membranes with highly homogenized nanopores for ultrafast water purification. Nat. Sustain. 7, 901–909 (2024).
Guo, H. et al. High-efficiency capture and recovery of anionic perfluoroalkyl substances from water using PVA/PDDA nanofibrous membranes with near-zero energy consumption. Environ. Sci. Technol. Lett. 8, 350–355 (2021).
Ma, D. et al. Absolute and fast removal of viruses and bacteria from water by spraying-assembled carbon-nanotube membranes. Environ. Sci. Technol. 55, 15206–15214 (2021).
Baer, A. & Kehn-Hall, K. Viral concentration determination through plaque assays: using traditional and novel overlay systems. J. Vis. Exp. 93, e52065 (2014).
Acknowledgements
The work was substantially supported by the Research Grants Council of the Hong Kong Special Administration Region, China (SRFS2021-7S04, C.Y.T.).
Author information
Authors and Affiliations
Contributions
B.G., L.E.P. and C.Y.T. conceived the idea and designed the research. B.G., W.L., Z.W. and Y.H. performed the experiments. Z.Y., Q.G., P.-F.S. and Q.X. provided constructive suggestions for the results. B.G., L.E.P. and C.Y.T. contributed to the writing of the manuscript.
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Peer review
Peer review information
Nature Water thanks Xiao-mao Wang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Supplementary Information (download PDF )
Supplementary Discussion, Methods, Figs. 1–29, Videos 1 and 2, and Table 1.
Supplementary Video 1 (download MP4 )
The filtration process of the Fr-uPA purifier.
Supplementary Video 2 (download MP4 )
Video showing that the manual pump is easy to operate by hand.
Source data
Source Data Figs. 2–5 (download XLS )
Statistical source data.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Gan, B., Hu, Y., Liu, W. et al. Fractal-inspired ultrapermeable membranes for electricity-free portable nanofiltration. Nat Water 4, 68–77 (2026). https://doi.org/10.1038/s44221-025-00551-3
Received:
Accepted:
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s44221-025-00551-3
This article is cited by
-
Purifying water with manual pumping
Nature Water (2026)


