Fig. 1: Increased nitrofurantoin prescribing is not associated with increased nitrofurantoin resistance (twelve-month rolling averages, data from England, 2015—2023).
From: Insights into durability against resistance from the antibiotic nitrofurantoin
A Count of nitrofurantoin and trimethoprim prescriptions. B Resistance to nitrofurantoin and trimethoprim in E. coli and other coliforms isolated from urine. Vertical dashed lines in A and B indicate date of switch to nitrofurantoin as first-choice antibiotic. C Resistance and nitrofurantoin prescribing for each of the 42 healthcare regions in England (Integrated Care Boards, ICBs), averaged across the twelve-month period ending in December 2023 (grey areas denote 95% confidence interval for the linear regression; clipped symbols at the bottom of the plot denote ICBs with 0% recorded resistance). Data from the UK Office for Health Improvement and Disparities Fingertips data collection9.
