Fig. 6: A time-sequenced diagram of the 4-week experimental period that occurred after the 12-week growth period.

During the experimental period, 0d represents the initial conditions prior to the sub-MIC ciprofloxacin exposure, *1d represents the first day of sub-MIC ciprofloxacin exposure after it is initially administered, *12d is the final day of the sub-MIC ciprofloxacin exposure where the bulk water is completely replaced after the final samples are taken, and +14d is 14 days after the bulk water replacement where there is no ciprofloxacin remaining, allowing the biofilm to recover. Red dots represent the ciprofloxacin.