Table 1 Cohort clinical characteristics.

From: Temporal evolution and inter-patient heterogeneity in primary and recurrent head and neck squamous cell carcinoma

Patient

Age

Sex

Smoking

Primary tumour site and stage

HPV status

Primary treatment

Adjuvant therapy

Recurrence/metastasis

P01

59

M

Yes

Oral cavity T2N0M0

+

Resection

None

Locoregional and distant (lung and liver)

P02

43

F

Ex-smoker

Oral cavity T4N2bM0

Resection

RT

Locoregional

P03

55

M

No

Oral cavity T1N0M0

Resection

None

Locoregional

P04

74

M

Ex-smoker

Hypopharynx T3N2bM0

RT

NA

Locoregional and distant (pleural effusion)

P05

68

M

Yes

3 primaries:

Oropharynx

T1N0M0

Oral cavity

T2N2cM0

Hypopharynx

T1N0M0

Resection

None

Locoregional

P06

51

M

Ex-smoker

Oral cavity T2N1M0

Resection

RT

Locoregional

P07

50

M

No

Oral cavity T1N1M0

Resection

None (declined RT)

Locoregional

P08

56

F

No

Oral cavity T4AN0M0

Resection

RT

Locoregional

P09

39

M

Yes

Oral cavity T3N2cM0

Resection

Chemo-RT

Locoregional

  1. The column “HPV status” summarizes the results from p16 staining and PCR assay (see Table S1 for details).
  2. += positive, − = negative, RT = radiotherapy, NA = not applicable.