Table 1 Baseline patient characteristics.
Baseline characteristics of 146 patients undergoing | |
Glioma surgery and Whole Genome Sampling | |
Male: Female ratio | 65:35 |
Median age (years) | 52.9 + /-14.9 |
Neuropathology diagnosis | |
Pilocytic Astrocytoma (WHO 1) | n = 1 (0.7%) |
Oligodendroglioma (WHO 2) | n = 5 (3.4%) |
Oligodendroglioma (WHO 3) | n = 8 (5.5%) |
Astrocytoma (WHO 2) | n = 8 (5.5%) |
Astrocytoma (WHO 3) | n = 14 (9.6%) |
Astrocytoma (WHO 4) | n = 12 (8.2%) |
Pleomorphic Xanthoastrocytoma (WHO 3) | n = 2 (1.4%) |
Atypical Teratoid Rhabdoid Tumour (WHO 4) | n = 1 (0.7%) |
Glioblastoma WHO 4 | n = 95 (65.1%) |
Median Tumour Content of WGS sample in relation to surgery performed | |
Craniotomy: Biopsy ratio | 91:9 |
Primary craniotomy: Redo craniotomy at tumour recurrence ratio | 90:10 |
Craniotomy Median Tumour Content (%) from ≥1 cm 3 sample | 69% ( + /-34%) |
Needle biopsy Median Tumour Content (%) from 1 × 0.2 cm core sample | 73% ( + /-19%) |
WGS Pertinent Germline mutation requiring referral to geneticist | |
Pertinent Germline mutation | 4% |
