Table. 3 Univariable and multivariable analyses of risk factors associated with receipt of bilateral mastectomy among women who were diagnosed with operable breast cancer and underwent germline genetic testing for hereditary breast and ovarian cancer (HBOC)

Age at diagnosis, years

 <40

10.35 (6.23, 17.18)

<0.001

10.39 (5.92, 18.23)

<0.001

 40–49

4.47 (2.83, 7.05)

<0.001

5.09 (3.08, 8.42)

<0.001

 50–59

3.87 (2.35, 6.36)

<0.001

4.24 (2.48, 7.26)

<0.001

 > = 60

Reference

Reference

Genetic counseling type

 In-person

Reference

Reference

 Telehealth

1.34 (0.79, 2.24)

0.276

1.35 (0.72, 2.54)

0.353

 Oncologist-Led

0.51 (0.36, 0.73)

<0.001

0.87 (0.58, 1.31)

0.502

Race or ethnicity

 Non-Hispanic White

Reference

Reference

 Non-Hispanic Black

1.04 (0.67, 1.61)

0.861

0.98 (0.60, 1.60)

0.928

 Hispanic

1.14 (0.83, 1.58)

0.421

1.31 (0.91, 1.90)

0.152

 Asian

0.89 (0.55, 1.43)

0.618

0.89 (0.53, 1.52)

0.679

 Other or Unknown

0.69 (0.41, 1.19)

0.181

1.02 (0.55, 1.90)

0.940

Marital status

 Married

1.04 (0.79. 1.36)

0.792

Not in multivariable model

 Unmarried

Reference

 Unknown

1.30 (0.63, 2.67)

0.478

Stage

 0

1.09 (0.68, 1.75)

0.716

0.96 (0.57, 1.61)

0.872

 I

Reference

Reference

 II

1.79 (1.32, 2.44)

<0.001

1.35 (0.95, 1.91)

0.095

 III

1.68 (1.07, 2.65)

0.025

1.16 (0.69, 1.94)

0.568

Family history of breast cancer

 Yes

1.16 (0.89, 1.52)

0.280

1.30 (0.95, 1.77)

0.097

 No

Reference

Reference

Tumor hormone receptor-positive

 Yes

0.48 (0.35, 0.65)

<0.001

0.59 (0.41, 0.83)

0.003

 No

Reference

Reference

Genetic testing result

 P/LP

5.62 (3.81, 8.29)

<0.001

4.70 (3.03, 7.29)

<0.001

 VUS

1.03 (0.72, 1.47)

0.869

0.90 (0.61, 1.34)

0.599

 B/LB

Reference

Reference