Fig. 1: Potential hosts for the genesis of a zoonotic avian influenza virus.

Mammals infected with the current AIV H5N1 clade 2.3.4.4b present a significant risk for the emergence of zoonotic viruses. Human infections have been documented in a dairy cow farm worker. Human-adaptation markers have been identified in multiple isolates from mammals, raising concerns about the potential role of these animals as intermediate hosts for the emergence of zoonotic AIV H5N1. The figure was created with BioRender.com.