Fig. 1: Post-viral neurological sequelae.
From: Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps
Viruses can enter the CNS via brain–blood barrier disruption, transcellular, paracellular, or transsynaptic spread, or by infecting peripheral immune cells, which then cross into the CNS. Viral infection of the CNS can trigger neuronal death, disruption of neurogenesis, and dysregulation of the immune system. These disturbances in homeostasis can result in long-term neurological complications, such as cognitive deficits, seizures, headache, fatigue, mood disorders, and changes in personality and behavior. Figure created with BioRender.
