Fig. 1: 13C MR images, acquired at 3 T, of hyperpolarized 13C-labelled pyruvate, lactate and bicarbonate (overlaid on a T2-weighted 1H image) and 2H MR images, acquired at 9.4 T, of 2H-labelled glucose and Glx in the brains of healthy volunteers. | npj Imaging

Fig. 1: 13C MR images, acquired at 3 T, of hyperpolarized 13C-labelled pyruvate, lactate and bicarbonate (overlaid on a T2-weighted 1H image) and 2H MR images, acquired at 9.4 T, of 2H-labelled glucose and Glx in the brains of healthy volunteers.

From: Imaging cancer metabolism using magnetic resonance

Fig. 1: 13C MR images, acquired at 3 T, of hyperpolarized 13C-labelled pyruvate, lactate and bicarbonate (overlaid on a T2-weighted 1H image) and 2H MR images, acquired at 9.4 T, of 2H-labelled glucose and Glx in the brains of healthy volunteers.The alternative text for this image may have been generated using AI.

The 13C images are the sum of 20 images acquired over 60 s following the intravenous injection of 0.43 mL/kg of ~250 mM hyperpolarized [1-13C]pyruvate. The nominal image resolution was 1.5 × 1.5 × 2 cm3. The 2H images show three 10 min images, acquired between 91.5 and 121.5 min after oral administration of 0.75 g/kg body weight of [6,6’-2H2]glucose. The nominal image resolution was 1.5 × 1.54 × 1.29 cm3. Bicarbonate and Glx labelling are higher in the grey matter, reflecting increased TCA cycle activity in grey matter as compared to white matter. The images were taken, with permission, from49,50.

Back to article page